TNPSC Drug Inspector

TAMIL NADU PUBLIC SERVICE COMMISSION
SYLLABUS
PHARMACY/ PHARMACEUTICAL SCIENCES
(UG DEGREE STANDARD)
Code:4290
UNIT-I:

1) Historical background and development of profession of pharmacy: History
of profession of Pharmacy in India in relation to pharmacy education, industry and
organization, Pharmacy as a career, Pharmacopoeias: Introduction to IP, BP, USP
and Extra Pharmacopoeia.

2) Calculations:
Posology: Dose calculations based on age, body weight and surface area.
Pharmaceutical calculations: Percentage solutions, Alligation, Proof sprit and
isotonic solutions based on freezing point and molecular weight.

3) Surface & interfacial Phenomenon:
Measurement of surface and interfacial tensions, spreading coefficient, surface
active agents, HLB Scale, solubilisation and Detergency

4) pH, buffers and isotonic solution:
pH determination, applications of buffers, buffer equation, buffer capacity and
buffered isotonic solutions.

5) Unit Operations: Size reduction, size separation, mixing, filtration, centrifugation
evaporation, drying, distillation, heat transfer, compression and Tablet coating.

6) Coarse Dispersion:
Suspension, interfacial properties of suspended particles, settling in suspensions,
formulation of flocculated and deflocculated suspension. Emulsions and theories
of emulsification, micro emulsion and multiple emulsion, stability of emulsions,
preservation of emulsions, rheological properties of emulsions and emulsion
formation by HLB method.

7) Micromeritics: Particle size distribution, mean particle size, number and weight
distribution, particle number, methods of determining particle size by different
methods, specific surface, methods of determining surface area and derived
properties of powders.

8) Pre-formulation studies: Introduction to pre-formulation, goals and objectives,
study of physicochemical characteristics of drug substances
a. Physical Properties: Crystal & amorphous form, particle size, shape, flow
properties, solubility profile (Pka, pH, Partition co-efficient) Polymorphism.
b. Chemical properties: Hydrolysis, Oxidation, reduction racemisation,
polymerisation.
BCS classification of drugs and its significant
Application of preformulation considerations in the development of solid, liquid oral
and parenteral dosage forms and its impact on stability of dosage forms.

9) Pharmaceutical Excipients – Used in Liquid, Semisolids and solid dosage forms.

10)Quality Control Tests and Evaluation parameters of the following
formulations: Solid dosage forms, Semi solids, Liquid dosage forms, Parenteral,
Ophthalmic preparation and Pharmaceutical Aerosols.

11)Cosmetics: Formulation and preparation of the following cosmetics preparationsLipsticks, Shampoos, Cold Cream, Vanishing Cream, Tooth Paste, Hair Dyes and
Sunscreens.

12)Packaging Material Sciences: Materials used for packaging of Pharmaceutical
Products, factors influencing choice of containers, legal and official requirement
for containers, Quality control tests for containers and rubber closures.

13)Bio availability and Bioequivalence: Definitions and objectives of
Bioavailability, absolute and relative bioavailability, measurement of bioavailability
in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence
studies, methods to enhance dissolution rates and bioavailability of poorly soluble
drugs.

14)Pharmacokinetics: Definition and introduction to Pharmacokinetics,
Compartment models, Non-compartment models, Physiological models, One
compartment open model
a) Intravenous Injection (bolus)
b) Intravenous infusion
c) Extra vascular administrations.
Pharmacokinetic parameters – KE, T½, Vd, AUC, Ka, CLt and CLR – definitions,
methods of elimination, understanding of their significance and application.

15)Good manufacturing practices (GMP)

16)Good Laboratory practices (GLP): Organisation and personnel, Facilities,
equipment, Testing facilities operation, Test and control articles, Protocol for
conduct of a Nonclinical Laboratory Study, Records and reports, Disqualification
of Testing facilities.

17)Warehousing: Good Warehousing practice, Materials Management.

18)Pilot Plant Scale up Techniques: General considerations – including
significance of personnel requirements, space requirements, raw materials, Pilot
plant scale up considerations for solids, liquid orals, semi solids and relevant
documentation, SUPAC guidelines, Introduction to platform technology.

19)Quality management systems: Quality management and certification: concept
of quality, Total quality management, Quality by Design (QbD), six sigma concept,
out of specifications (OOS) change control, Introduction to ISO 9000 series of
quality system standards, ISO 14000, NABL.

20)Indian Regulatory Requirements: Central Drug Standard Control Organisation
(CDSCO) and State Licensing Authority, Organisation, Responsibilites, Certificate
of Pharmaceutical products (COPP) Regulatory requirements and approval
procedures for New drugs.

21)Over the counter (OTC) Sales: Introduction and sale of over the counter and
Rational use of common over the counter medications.

22)Drug Store Management and Inventory Control: Organisation of Drug Store,
types of materials stocked and storage conditions. Purchase and inventory
control: Principles, Purchase procedures, Purchase order, Procurement and
stocking, Economic order quantity, Reorder quantity level and methods used for
the analysis of the drug expenditure.

23)Novel Drug Delivery Systems: Ocular Drug Delivery Systems, Transdermal
Drug Delivery Systems, Implantable Newer Drug Delivery Systems, Targeted
Drug Delivery and Controlled Drug Delivery Systems.